Research Shows Topical TXA in Joint Replacements Lowers Blood Transfusion Use

Orthopedic surgeons from The Miriam Hospital have conducted a cost-benefit analysis of topical tranexamic acid (TXA) in primary total hip and knee arthroplasty patients that revealed a 12 percent transfusion rate reduction — from 17.5 percent to 5.5 percent — with no significant difference in complication rates.

Besides reducing the risk for postoperative bleeding and transfusion after total joint replacement, use of topical TXA enabled approximately 9.3 percent more patients to be discharged to home rather than to a skilled nursing facility. The study and its findings have been published in The Journal of Arthroplasty.

“Historically, with hip or knee replacement, there was a 25 to 30 percent chance of a blood transfusion,” said John Froehlich, M.D., program director of the Total Joint Center at The Miriam Hospital and a principal investigator on the study. “We realized that this high frequency of transfusions was associated with longer hospital stays and a higher risk of infections, which we are always working to avoid. Tranexamic acid has been around for 30 years, but because there was concern about the danger of administering it intravenously, we opted to inject it in the joints. We found it to be effective in reducing ongoing blood loss and the subsequent need for transfusion, and we have now standardized the practice.”

The reduction of perioperative blood transfusions in total joint arthroplasty has been an ongoing goal in the effort to deliver more efficient and effective healthcare. According to several studies, blood transfusions may add a 3 percent to 20 percent risk of postoperative infection. Perioperative transfusion adds both cost to the procedure and risk to the patient, including joint infection, allergic reaction and viral transmission, which led to The Miriam’s analysis of topical TXA in primary hip and knee arthroplasty.

Tranexamic acid is a synthetic derivative of the amino acid lysine, and produces antifibrinolytic activity by competitively inhibiting lysine binding sites on plasminogen molecules. Through this process, TXA helps the body stabilize blood clot formation, thereby reducing bleeding at surgical sites. Most protocols of TXA in total joint arthroplasty have involved intravenous delivery of TXA. However, a theoretical concern for the possibility of causing new blood clots in veins may be why intravenous TXA implementation has been slow to progress. A growing number of studies have indicated that intraarticular, or topical, injection administration may provide advantages. These include potentially reduced costs with a single injection, surgeon control, and localization and concentration of the drug more precisely at the surgical site.

“As the evidence for topical TXA grew, our arthroplasty surgeons started adopting topical TXA for total joint arthroplasty,” added Froehlich, “and The Total Joint Center at The Miriam Hospital has seen a marked reduction in transfusion rates, saving $83.73 per patient based on transfusion costs alone after accounting for the cost of TXA.”

Conducted from March 2012 to March 2013, The Miriam’s study of topical TXA included 591 consecutive patients undergoing primary hip or knee arthroplasty by five surgeons. Of those, 311 patients received topical TXA and 280 were control patients. On Sept. 1, 2012, surgeons started administering topical TXA to all total joint patients intraoperatively. The months of August and September 2012 were excluded from the study to prevent overlap. The proportion of patients was similar between the two cohorts for each surgeon, and bilateral total joints, revision joints, and fractures requiring arthroplasty were excluded from the study.

Results showed that with use of topical TXA in total joint arthroplasty, blood transfusion usage fell 12 percent, surgical care costs decreased, and hospital stays shrunk as patients bypassed rehabilitation instead were discharged home.

“Topical TXA for total joint replacement allows us to do a better job of getting people home and better sooner,” said Lee Rubin, M.D., an orthopedic surgeon with the Total Joint Center at The Miriam Hospital, also a principal investigator on the study. “It reduces transfusion rates, increases home disposition, and reduces cost in primary hip and knee arthropolasty. If we can reduce the infection rate after these surgeries, we will change people’s lives in a very positive way, save millions of health care dollars a year nationally, and improve total joint replacement outcomes and quality of care. Perhaps most importantly, we have now developed a simple, standardized, and cost-effective protocol for the use of topical TXA during total joint replacement that can be immediately used by any surgeon around the world to improve patient care.”

The Miriam Hospital is a 247-bed, not-for-profit teaching facility in Providence, R.I., affiliated with The Warren Alpert Medical School of Brown University.